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HomeProductsNew Chemical MaterialsPharmaceutical Intermediates Cas 898543-06-1

Pharmaceutical Intermediates Cas 898543-06-1

Payment Type:
L/C,T/T,D/P
Incoterm:
FOB,CFR,CIF,CPT,CIP
Min. Order:
1 Bag/Bags
Delivery Time:
10 Days
Transportation:
Ocean,Air
Port:
Shanghai,Beijing,Qingdao
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  • Product Description
Overview
Product Attributes

BrandYFL

Supply Ability & Additional Informations

Packaging200L/PE Drum

Productivity2000MT/A

TransportationOcean,Air

Place of OriginShandong Prov.

Supply Ability2000MT/A

PortShanghai,Beijing,Qingdao

Payment TypeL/C,T/T,D/P

IncotermFOB,CFR,CIF,CPT,CIP

Delivery Time10 Days

Packaging & Delivery
Selling Units:
Bag/Bags
Package Type:
200L/PE Drum

Ethyl difluorobromoacetate belongs to ester derivatives and can be used as Pharmaceutical Intermediates.

Ethyl difluorobromoacetate compounds are an intermediate for the synthesis of drugs and high-energy materials, such as ethyl difluorobromoacetate, which is an intermediate for the anti-tumor drug gemcitabine.

Preparation methods step 1, by two fluorine dibromomethane preparation two fluorine bromine acetonitrile to add 90 grams of cuprous cyanide powder to 500 ml of 1:1 (volume), N, N - dimethyl formamide (DMF)/ethylene glycol dimethyl ether (DME) in the mixed solvent, catalyst and add 1 gram of diphenyl and 18 - crown - 6, slowly add Moore measuring two fluorine dibromomethane soluble in DMF/DME (volume ratio 1:1) in the mixed solution, the temperature of 20 ℃ under the condition of reaction started monitoring, half an hour with GC (chromatographic column:

PEG-20M) until the conversion rate is 8Chemicalbook0 %.

The temperature was slowly raised to 50℃, and the difluorobromoacetonitrile was evaporated, and then the difluorobromoacetonitrile was collected at low temperature through cold Wells below 0℃.

Step 2, by two fluorine bromine acetonitrile were two fluorine bromine ethyl acetate to 78 grams (0.5 mol) two fluorine bromine acetonitrile dissolved in 400 ml of 95% (mass fraction, the same below) in ethanol solution, add 10 ml of 50% (mass fraction, the same below) sulfuric acid solution, heating to 30 ℃, insulation stirring for 10 hours, slowly heating reflux 5 hours, through distillation, with GC (capillary chromatographic column: PEG - 20 m), detection to collect appropriate components, 60.5 grams of two fluorine bromine ethyl acetate, the purity of product was 99.0%.

Chemical properties Boiling point 112℃, density 1.583.

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Product Categories : New Chemical Materials

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